Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6

With this motto in mind, we now have turn out to be amongst quite possibly the most technologically innovative, cost-efficient, and price-competitive manufacturers for Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6, We look forward to supplying you with our products in the near future, and you will find our quotation is very reasonable and the quality of our products is very excellent!
With this motto in mind, we now have turn out to be amongst quite possibly the most technologically innovative, cost-efficient, and price-competitive manufacturers for China Ibrutinib N-3 and Intermediates, So far our products have been exported to east Europe, the Middle East, Southeast, Africa and South America etc. We have 13years professional sales and purchase in Isuzu parts at home and abroad and the ownership of the modernized electronic Isuzu parts checking systems. We honor our core principal of Honesty in business, priority in service and will do our best to offer our customers with high quality products and excellent service.

Intermediate for the synthesis of allopurinol.

It is one of the 3-amino-4-substituted pyrazole series. It can be used as an intermediate to synthesize many pharmacologically effective organic compounds, such as allopurinol, one of the pyrazolopyrimidine derivatives series, the latter since 1963 Since its clinical use, it has been the main drug for the treatment of gout. At present, there are few known methods for synthesizing

3-aminopyrazole-4-carboxamide hemisulfate in China, mainly by reacting malononitrile and triethyl orthoformate to prepare ethoxymethylene malononitrile, and then with The reaction of hydrazine hydrate yields 3-amino-4-cyanopyrazole, which is finally reacted with concentrated sulfuric acid to produce

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), the total yield of synthesis by this method is about 60% (calculated as malononitrile), this method It involves a three-step reaction, the steps are longer, and the reagents used, such as malononitrile and ethoxymethylene malononitrile, are more toxic and expensive. In addition, the 3-aminopyrazole-4 prepared by this method -Formamide hemisulfate has a color that is difficult to remove and requires additional processing, which is more complicated.

There are reports in foreign literature using pyridylamide hydrazone and ethoxymethylene malononitrile as raw materials to obtain 3-amino-4-cyanopyrazole by addition and cyclization, and then react with concentrated sulfuric acid to obtain the target compound (Reuken G Jones. Reactions of orthoesters with activemethylene compounds[J]. J Am Chem Soc. 1952,74(5) :4889 4891). The main raw materials used in this method are expensive, the reaction yield is not high, and the profit of industrial production is low. It must be difficult.

Executive standard: Enterprise Standard
Exterior: Off-white or yellow powder

Package: 25kg/drum
assay（HPLC）content Greater than or equal to 98.0%
purity（HPLC）content Greater than or equal to 99.5%

JIN DUN Medical has ISO qualification and meets GMP production standards, employed domestic and foreign drug synthesis experts with rich experience to guide company’s R&D.

TECHNOL OGY ADVANTAGES
●High Pressure Catalytic Hydrogenation . High Pressure Hydrogenolysis Reaction . Cryogenic Reaction (<-78%C)
●Aromatic Heterocyclic Synthesis
●Rearrangement Reaction
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira . Gignard Reaction

Equipments

Our Lab has various experimental and testing equipments, such as: NMR (Bruker 400M)、HPLC、chiral-HPLC、LC-MS、LC-MS/MS (API 4000)、IR、UV、GC、GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope…

R&D Team

Jindun Medical has a group of professional R&D personnel, and employs many domestic and foreign drug synthesis experts to guide R&D, making our synthesis more accurate and efficient.

We have helped several top domestic pharmaceutical companies, such as Hansoh, Hengrui and HEC Pharm. Here we will show part of them.

Customzation Case One:

Cas No.: 110351-94-5

Customzation Case Two:

Cas No.: 144848-24-8

Customzation Case Three:

Cas No.: 200636-54-0

1.Customize New Intermediates or APIs. Same as above case sharing, customers have the demands for specific Intermediates or APIs, and they can not find the needed products in the market,  then we can help to Customize.

2.Process Optimization for Old Products. Our team will help to Optimize and improve such production whose reaction route is old, production cost is high, and the efficiency is low. We can provide full documentation for technology transfer and process improvement, help customer for a more efficient production.

From drug targets to INDs, JIN DUN Medical provides you with one-stop personalized R&D solutions.

JIN DUN Medical insists on creating a team with dreams, making dignified products, meticulous, rigorous, and going all out to be a trusted partner and friend of customers!

With this motto in mind, we now have turn out to be amongst quite possibly the most technologically innovative, cost-efficient, and price-competitive manufacturers for Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6, We look forward to supplying you with our products in the near future, and you will find our quotation is very reasonable and the quality of our products is very excellent!
Wholesale China Ibrutinib N-3 and Intermediates, So far our products have been exported to east Europe, the Middle East, Southeast, Africa and South America etc. We have 13years professional sales and purchase in Isuzu parts at home and abroad and the ownership of the modernized electronic Isuzu parts checking systems. We honor our core principal of Honesty in business, priority in service and will do our best to offer our customers with high quality products and excellent service.