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2- cyano -5- fluorine benzyl bromide is used as the intermediate of Trelagliptin succinate .
Trogliptin succinate is a dipeptidyl peptidase Ⅳ (DPP – Ⅳ) inhibitor developed by Takeda (Takeda Pharmaceutical Co., Ltd.) in Japan. It can selectively and continuously inhibit DPP – Ⅳ and control blood glucose level. Clinical trials show that the drug has good safety and effectiveness. Once a week can effectively control the blood glucose level and improve the medication compliance of patients. In May, 2015, the drug was approved by Japan PMDA to be listed for the treatment of diabetes.

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