• NEBANNER

Leading Manufacturer for Endogenous Analgesia - 3-Amino-4-pyrazole carbosamide hemisulfate – JIN DUN

Leading Manufacturer for Endogenous Analgesia - 3-Amino-4-pyrazole carbosamide hemisulfate – JIN DUN

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

Our rewards are reduce selling prices,dynamic revenue team,specialized QC,sturdy factories,superior quality services for Lurasidone Hydrochloride, Water Treatment Machine, Reverse Osmosis Filter System, We sincerely welcome overseas buyers to consult for that long-term cooperation as well as the mutual progress.
Leading Manufacturer for Endogenous Analgesia - 3-Amino-4-pyrazole carbosamide hemisulfate – JIN DUN Detail:

Intermediate for the synthesis of allopurinol.

It is one of the 3-amino-4-substituted pyrazole series. It can be used as an intermediate to synthesize many pharmacologically effective organic compounds, such as allopurinol, one of the pyrazolopyrimidine derivatives series, the latter since 1963 Since its clinical use, it has been the main drug for the treatment of gout. At present, there are few known methods for synthesizing

3-aminopyrazole-4-carboxamide hemisulfate in China, mainly by reacting malononitrile and triethyl orthoformate to prepare ethoxymethylene malononitrile, and then with The reaction of hydrazine hydrate yields 3-amino-4-cyanopyrazole, which is finally reacted with concentrated sulfuric acid to produce

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), the total yield of synthesis by this method is about 60% (calculated as malononitrile), this method It involves a three-step reaction, the steps are longer, and the reagents used, such as malononitrile and ethoxymethylene malononitrile, are more toxic and expensive. In addition, the 3-aminopyrazole-4 prepared by this method -Formamide hemisulfate has a color that is difficult to remove and requires additional processing, which is more complicated.

There are reports in foreign literature using pyridylamide hydrazone and ethoxymethylene malononitrile as raw materials to obtain 3-amino-4-cyanopyrazole by addition and cyclization, and then react with concentrated sulfuric acid to obtain the target compound (Reuken G Jones. Reactions of orthoesters with activemethylene compounds[J]. J Am Chem Soc. 1952,74(5) :4889 4891). The main raw materials used in this method are expensive, the reaction yield is not high, and the profit of industrial production is low. It must be difficult.

Executive standard: Enterprise Standard
Exterior: Off-white or yellow powder

Package: 25kg/drum
assay(HPLC)content Greater than or equal to 98.0%
purity(HPLC)content Greater than or equal to 99.5%


Product detail pictures:

Leading Manufacturer for Endogenous Analgesia - 3-Amino-4-pyrazole carbosamide hemisulfate – JIN DUN detail pictures


Related Product Guide:

We pursue the administration tenet of "Quality is remarkable, Services is supreme, Status is first", and will sincerely create and share success with all customers for Leading Manufacturer for Endogenous Analgesia - 3-Amino-4-pyrazole carbosamide hemisulfate – JIN DUN , The product will supply to all over the world, such as: luzern, The Swiss, Georgia, We have more than 8 years of experience in this industry and have a good reputation in this field. Our products have won praise from customers worldwide. Our aim is to help customers realize their goals. We are making great efforts to achieve this win-win situation and sincerely welcome you to join us.
  • This is a very professional and honest Chinese supplier, from now on we fell in love with the Chinese manufacturing.
    5 Stars By Ella from India - 2017.07.07 13:00
    This is a very professional wholesaler, we always come to their company for procurement, good quality and cheap.
    5 Stars By Sharon from Vancouver - 2018.09.21 11:01
    Write your message here and send it to us