L-Valine
L-Valine
L-Valine is used as the intermediate of Valaciclovir.
Valacyclovir is a guanine analogue antiviral drug. It is used in the clinical treatment of herpes simplex and herpes zoster infection in sexually transmitted diseases. This product is the precursor of acyclovir. It is absorbed rapidly after oral administration and quickly transformed into acyclovir in the body. Its antiviral effect is played by acyclovir. After acyclovir enters herpes infected cells, it competes with deoxynucleoside for virus thymidine deoxynucleoside kinase or cell kinase, and the drug is phosphorylated into activated acyclic guanosine triphosphate. As the substrate of virus replication, acyclovir competes with deoxyguanine triphosphate for virus DNA polymerase, which inhibits virus DNA synthesis and shows antiviral effect. The antiviral activity of this product in vivo is better than acyclovir, and the treatment index of herpes simplex virus type I and type II is 42.91% and 30.13% higher than acyclovir respectively. It also has high curative effect on varicella zoster virus.
JIN DUN Medical has ISO qualification and meets GMP production standards, employed domestic and foreign drug synthesis experts with rich experience to guide company's R&D.
TECHNOL OGY ADVANTAGES
●High Pressure Catalytic Hydrogenation . High Pressure Hydrogenolysis Reaction . Cryogenic Reaction (<-78%C)
●Aromatic Heterocyclic Synthesis
●Rearrangement Reaction
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira . Gignard Reaction
Equipments
Our Lab has various experimental and testing equipments, such as: NMR (Bruker 400M)、HPLC、chiral-HPLC、LC-MS、LC-MS/MS (API 4000)、IR、UV、GC、GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope...
R&D Team
Jindun Medical has a group of professional R&D personnel, and employs many domestic and foreign drug synthesis experts to guide R&D, making our synthesis more accurate and efficient.
We have helped several top domestic pharmaceutical companies, such as Hansoh, Hengrui and HEC Pharm. Here we will show part of them.
Customzation Case One:
Cas No.: 110351-94-5
Customzation Case Two:
Cas No.: 144848-24-8
Customzation Case Three:
Cas No.: 200636-54-0
1.Customize New Intermediates or APIs. Same as above case sharing, customers have the demands for specific Intermediates or APIs, and they can not find the needed products in the market, then we can help to Customize.
2.Process Optimization for Old Products. Our team will help to Optimize and improve such production whose reaction route is old, production cost is high, and the efficiency is low. We can provide full documentation for technology transfer and process improvement, help customer for a more efficient production.
From drug targets to INDs, JIN DUN Medical provides you with one-stop personalized R&D solutions.
JIN DUN Medical insists on creating a team with dreams, making dignified products, meticulous, rigorous, and going all out to be a trusted partner and friend of customers!
![4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride](https://cdn.globalso.com/jindunchem-med/dc3948321-300x300.jpg)