factory customized Abilify Aripiprazole - 3-Amino-4-pyrazole carbosamide hemisulfate – JIN DUN

Short Description:

Product Detail

Product Tags

Feedback (2)

To be the stage of realizing dreams of our employees! To build a happier, more united and more professional team! To reach a mutual benefit of our customers, suppliers, the society and ourselves for Intermediates And Apis Such As Mi Rafting Peptide, Water Conditioning, Wastewater Treatment System, With the development of society and economy, our company will keep a tenet of "Focus on trust, quality the first", moreover, we expect to create a glorious future with every customer.

factory customized Abilify Aripiprazole - 3-Amino-4-pyrazole carbosamide hemisulfate – JIN DUN Detail:

Intermediate for the synthesis of allopurinol.

It is one of the 3-amino-4-substituted pyrazole series. It can be used as an intermediate to synthesize many pharmacologically effective organic compounds, such as allopurinol, one of the pyrazolopyrimidine derivatives series, the latter since 1963 Since its clinical use, it has been the main drug for the treatment of gout. At present, there are few known methods for synthesizing

3-aminopyrazole-4-carboxamide hemisulfate in China, mainly by reacting malononitrile and triethyl orthoformate to prepare ethoxymethylene malononitrile, and then with The reaction of hydrazine hydrate yields 3-amino-4-cyanopyrazole, which is finally reacted with concentrated sulfuric acid to produce

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), the total yield of synthesis by this method is about 60% (calculated as malononitrile), this method It involves a three-step reaction, the steps are longer, and the reagents used, such as malononitrile and ethoxymethylene malononitrile, are more toxic and expensive. In addition, the 3-aminopyrazole-4 prepared by this method -Formamide hemisulfate has a color that is difficult to remove and requires additional processing, which is more complicated.

There are reports in foreign literature using pyridylamide hydrazone and ethoxymethylene malononitrile as raw materials to obtain 3-amino-4-cyanopyrazole by addition and cyclization, and then react with concentrated sulfuric acid to obtain the target compound (Reuken G Jones. Reactions of orthoesters with activemethylene compounds[J]. J Am Chem Soc. 1952,74(5) :4889 4891). The main raw materials used in this method are expensive, the reaction yield is not high, and the profit of industrial production is low. It must be difficult.

Executive standard: Enterprise Standard
Exterior: Off-white or yellow powder

Package: 25kg/drum
assay（HPLC）content Greater than or equal to 98.0%
purity（HPLC）content Greater than or equal to 99.5%

Product detail pictures:

Related Product Guide:

Fast and very good quotations, informed advisers to help you choose the correct merchandise that suits all your preferences, a short creation time, responsible excellent command and different companies for paying and shipping affairs for factory customized Abilify Aripiprazole - 3-Amino-4-pyrazole carbosamide hemisulfate – JIN DUN , The product will supply to all over the world, such as: Oman, Johor, Brunei, Honest to every customers are our requested! First-class serve, best quality, best price and fastest delivery date is our advantage! Give every customers good serve is our tenet! This makes our company get the favour of customers and support! Welcome all over the world customers send us enquiry and looking forward your good co-operation !Please your inquiry for more details or request for dealership in selected regions.

Cyanide Treatment In Wastewater