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China Gold Supplier for Flupentixol Depot - 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride – JIN DUN

China Gold Supplier for Flupentixol Depot - 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride – JIN DUN

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China Gold Supplier for Flupentixol Depot - 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride – JIN DUN Detail:

12.The intermediate 4-(4-aminophenyl)-3-morpholinone (1) of the anticoagulant rivaroxaban was prepared by two methods: ①Bromobenzene was successively reacted with ethanolamine and chloroacetyl chloride to obtain 4-benzene The morpholinone is then nitrated to reduce to 1, and the total yield is about 32%; ②Bromobenzene is first nitrated, and then reacted with ethanolamine to obtain 2-(4-nitroanilino)ethanol, which is then closed by chloroacetyl chloride. The reduction reaction produces 1, and the total yield is about 47%.

Rivaroxaban is a new type of anticoagulant that can be directly taken orally. It directly inhibits the activation of coagulation factor Xa, has a definite anticoagulant effect, does not require continuous monitoring, and has high safety. With the clinical application of rivaroxaban , The demand for rivaroxaban will gradually increase. The chemical name of rivaroxaban is 5-chloro-N-(((5S) -2-oxo-3-[4- (3-oxo- 4-morpholinyl)phenyl)-1,3-oxazolidine-5-yl)methyl-2-thiophenecarboxamide. There are currently two synthetic routes reported in the literature, and both routes are used An intermediate 4-(4-aminophenyl)-3-morpholinone. Although there are reports on the synthesis of 4-(4-aminophenyl)-3-morpholinone at home and abroad, there is a relatively high price of reaction raw materials. High, difficult to buy, or the reaction operation requirements are too high, difficult to grasp, not conducive to environmental protection and other deficiencies, and do not meet the requirements of industrialized mass production. Optimize the key intermediate of rivaroxaban 4-(4-aminophenyl)- The production process of 3-morpholinone and the reduction of the price of raw materials will definitely promote the promotion and application of rivaroxaban. There is no report on the synthesis of rivaroxaban in China. We are at rivaroxaban The key intermediate 4-(4-aminophenyl)-3-morpholinone synthetic route and technology have been innovatively studied. Two bromobenzene and p-nitrobromobenzene as starting materials are proposed. Process route. Focus on the cyclization process of 3-morpholinone ring.

Executive standard: enterprise standard
Exterior: White crystalline powder

Package: 25kg/drum
assay(HPLC)Content greater than or equal to 98.0%


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China Gold Supplier for Flupentixol Depot - 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride – JIN DUN detail pictures


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Our objective is to present premium quality products at aggressive prices, and top-notch services to buyers around the world. We have been ISO9001, CE, and GS certified and strictly adhere to their excellent specifications for China Gold Supplier for Flupentixol Depot - 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride – JIN DUN , The product will supply to all over the world, such as: Peru, Macedonia, Iceland, Adhering to the principle of "Enterprising and Truth-Seeking, Preciseness and Unity", with technology as the core, our company continues to innovate, dedicated to providing you with the highest cost-effective products and meticulous after-sales service. We firmly believe that: we are outstanding as we are specialized.
  • The factory has advanced equipment, experienced staffs and good management level, so product quality had assurance, this cooperation is very relaxed and happy!
    5 Stars By Mag from Miami - 2017.02.18 15:54
    We feel easy to cooperate with this company, the supplier is very responsible, thanks.There will be more in-depth cooperation.
    5 Stars By June from kazakhstan - 2017.12.19 11:10
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