4-(1-piperidino)piperidine; 1,4′-bipiperidine

4-(1-piperidino)piperidine; 1,4'-bipiperidine is used as the intermediate of Irinotecan.
Irinotecan antitumor drug. It is an inhibitor of DNA synthesis. It is a semi synthetic derivative of camptothecin; Used for preparing irinotecan hydrochloride and irinotecan hydrochloride trihydrate; Large scale clinical trials have shown that irinotecan hydrochloride has obvious inhibitory effects on a variety of tumors, such as colon cancer, small cell lung cancer, rectal cancer and leukemia, and is still effective in fluorouracil resistant cases. Therefore, irinotecan hydrochloride has attracted extensive attention all over the world.